LONG-TERM NON-PROGRESSOR (LTNP) HIV INFECTION. A CASE REPORT OF AN 81-YEAR-OLD WOMAN

Autores

  • Marcel Gonçalves Maciel
  • Francielle de Luna Souto
  • Joyce Michele Souza de Souza
  • Luiz Henrique Gonçalves Maciel
  • Oberdan Henrique Moreira Tavares
  • Michael Nosano Yakubu

DOI:

https://doi.org/10.25110/arqsaude.v27i3.2023-005

Palavras-chave:

Long-Term Non-Progressor, HIV, Old Woman

Resumo

An 81-year-old woman, long-term non-progressor HIV infected, asymptomatic, not using ART, with a seven-year clinical follow-up in a reference unit, TCD4+ cell count values ​​ranged from 719 to 1151 cells/µl, TCD8+ from 579 to 897 cells/µl and a viral load with higher value of 51 viral copies/ml but with undetectable results in most of the tests performed. The report of the long-term non-progressor HIV carrier aged over 80 years is somewhat unusual, considering the physiological/immunological changes that occur with the aging process concomitantly with HIV infection.

Referências

BORREL, M. et al. High rates of long‐term progression in HIV‐1‐positive elite controllers. Journal of the International AIDS Society, v. 24, n. 2, p. 25675, 2021.

BRASIL. Ministério da Saúde. Boletim Epidemiológico. HIV/AIDS/2021. Brasília: Ministério da Saúde. 2021.

BRASIL. Ministério da Saúde. Cuidado integral às pessoas que vivem com HIV pela Atenção Básica: manual para a equipe multiprofissional. Brasília: Ministério da Saúde. 2017.

GAARDBO, J. C. Thirty years with HIV infection-nonprogression is still puzzling: Lessons to Be Learned from Controllers and Long-Term Nonprogressors. AIDS Res Treat, 2012.

GEBARA, N. Y.; EL KAMARI V.; RIZK N. HIV-1 elite controllers: an immunovirological review and clinical perspectives. J Virus Erad, v. 18, n. 5, p. 163-166, 2019.

GORONZY J. J.; WEYAND C. M. Understanding immunosenescence to improve responses to vaccines. Nat. Immunol, v. 14, n. 5, p. 428-436, 2013.

NETO, A. V. et al. Síndrome da imunodeficiência adquirida (AIDS): descrição do primeiro caso autóctone do Brasil e estudo imunológico. Revista Paulista de Medicina, v. 101, n. 4, p. 165-168, 1983.

POROPATICH, K.; SULLIVAN, D. J. Human immunodeficiency virus type 1 long-term nonprogressors: the viral, genetic and immunological basis for disease non progression. J Gen Virol, v. 92, p. 247-268, 2011.

SABIN C. A.; LUNDGREN J. D. The natural history of HIV infection. Curr Opin HIV AIDS, v. 8, n.4, p. 311-7, 2013.

SOUZA, L. R. M. et al. Knowledge of PEP and PrEP among people living with HIV/AIDS in Brazil. BMC Public Health, v. 7, n. 21, 2021.

TAVARES, M. C. A. et al. Apoio social aos idosos com HIV/AIDS: uma revisão integrativa. Revista Brasileira de Geriatria e Gerontologia, v. 22, n. 2, p. 180168, 2019.

ZHANG Z. et al. Changes in NK Cell Subsets and Receptor Expressions in HIV-1 Infected Chronic Patients and HIV Controllers. Frontiers in immunology, v. 16, n. 12, p. 792775, 2021.

Downloads

Publicado

31-03-2023

Como Citar

MACIEL, Marcel Gonçalves; SOUTO, Francielle de Luna; DE SOUZA, Joyce Michele Souza; MACIEL, Luiz Henrique Gonçalves; TAVARES, Oberdan Henrique Moreira; YAKUBU, Michael Nosano. LONG-TERM NON-PROGRESSOR (LTNP) HIV INFECTION. A CASE REPORT OF AN 81-YEAR-OLD WOMAN. Arquivos de Ciências da Saúde da UNIPAR, [S. l.], v. 27, n. 3, p. 1123–1128, 2023. DOI: 10.25110/arqsaude.v27i3.2023-005. Disponível em: https://unipar.openjournalsolutions.com.br/index.php/saude/article/view/9418. Acesso em: 21 dez. 2024.

Edição

Seção

Artigos