IMPLICAÇÕES NEUROLÓGICAS DA MEDITAÇÃO DO TIPO TERAPIA COGNITIVA BASEADA EM MINDFULNESS EM PACIENTES COM TRANSTORNO DE ANSIEDADE OU TRANSTORNO DEPRESSIVO: UMA REVISÃO INTEGRATIVA

Autores

  • Bárbara Martins Machado Universidade Federal de Alfenas (UNIFAL)
  • Lara Koury Universidade Federal de Alfenas (UNIFAL)
  • Thiago Donizeth da Silva Universidade Professor Edson Antônio Velano (UNIFENAS)
  • Petrus Pires Marques Universidade Professor Edson Antônio Velano (UNIFENAS)
  • Daniel Martinez Saez Universidade Federal de Lavras (UFLA)
  • Evelise Aline Soares Universidade Federal de Alfenas (UNIFAL)
  • Flávia Da Ré Guerra Universidade Federal de Alfenas (UNIFAL)

DOI:

https://doi.org/10.25110/arqsaude.v27i9.2023-016

Palavras-chave:

Terapia Cognitiva-Comportamental, Cérebro, Transtornos Psiquiátricos, Antidepressivos

Resumo

A Terapia Cognitiva Baseada em Mindfulness (MBCT, do inglês Mindfulness-Based Cognitive Therapy) é uma técnica baseada na combinação da Terapia Cognitiva-Comportamental e da meditação mindfulness, na busca pela melhoria de sintomas psiquiátricos. O presente trabalho tem como objetivo a busca por publicações que discutam as implicações neurológicas de pacientes diagnosticados com transtorno depressivo e transtorno de ansiedade e que buscaram nessa técnica a melhoria de sua condição clínica ou qualidade de vida. Nossos resultados preliminares mostraram que os benefícios dessa prática foram colhidos na totalidade dos estudos encontrados, elucidando as áreas cerebrais modificadas e o motivo pelo qual elas foram ativadas. Procuramos abordar ainda a diferença entre essa técnica e o uso de medicamentos e tratamento usual.

Referências

ALLEN, M. et al. Cognitive-affective neural plasticity following active-controlled mindfulness intervention. The Journal of Neuroscience, [s. l.], 2012. Disponível em: https://pubmed.ncbi.nlm.nih.gov/23115195/. Acesso em: 19 mar. 2022.

ALMEIDA, N. O.; DEMARZO, M.; NEUFELD, C. B. Terapia cognitiva baseada em mindfulness no atendimento clínico individual de depressão. Rev. Eletrônica Saúde Mental Álcool Drog, v. 16, n. 3, p. 55-63, set. 2020. Disponível em: http://pepsic.bvsalud.org/scielo.php?script=sci_arttext&pid=S1806-69762020000300007&lng=pt&nrm=iso. Acesso em: 27 mar. 2022.

BAKKER, J. M. et al. The Two-Sided Face of Antidepressants: The Impact of Their Use on Real-Life Affective Change during Mindfulness-Based Cognitive Therapy. Psychotherapy and Psychosomatics, [s. l.], 5 abr. 2016. Disponível em: https://www.karger.com/Article/Pdf/443333. Acesso em: 7 mar. 2022.

BAPTISTA, M. N. Avaliando "depressões": dos critérios diagnósticos às escalas psicométricas. Aval. psicol., v. 17, n. 3, p. 301-310, 2018. Disponível em: http://pepsic.bvsalud.org/scielo.php?script=sci_arttext&pid=S1677-04712018000300004&lng=pt&nrm=iso. Acesso em: 20 mar. 2022.

BARNHOFER, T. et al. Mindfulness-based cognitive therapy (MBCT) reduces the association between depressive symptoms and suicidal cognitions in patients with a history of suicidal depression. Journal of Consulting and Clinical Psychology, [s. l.], 2015. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26302249/. Acesso em: 4 mar. 2022.

BATINK, T. et al. How does MBCT for depression work? Studying cognitive and affective mediation pathways. PLoS One, [s. l.], 23 ago. 2013. Disponível em: https://pubmed.ncbi.nlm.nih.gov/24009704/. Acesso em: 4 mar. 2022.

BOETTCHER, J. et al. Internet-Based Mindfulness Treatment for Anxiety Disorders: A Randomized Controlled Trial. Behavior Therapy, [s. l.], 2014. Disponível em: https://www.sciencedirect.com/science/article/pii/S0005789413001044. Acesso em: 11 mar. 2022.

BURGESS, E. E. et al. A Brief Mindfulness-Based Cognitive Therapy (MBCT) Intervention as a Population-Level Strategy for Anxiety and Depression. International Journal of Cognitive Therapy, [s. l.], 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33897938/. Acesso em: 1 mar. 2022.

CLADDER-MICUS, M. B. et al. Mindfulness‐based cognitive therapy for patients with chronic, treatment‐resistant depression: A pragmatic randomized controlled trial. Depress Anxiety, [s. l.], 2018. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175087/. Acesso em: 16 fev. 2022.

DESBORDES, G. et al. Effects of mindful-attention and compassion meditation training on amygdala response to emotional stimuli in an ordinary, non-meditative state. Frontiers in Human Neuroscience, [s. l.], 2012. Disponível em: https://pubmed.ncbi.nlm.nih.gov/23125828/. Acesso em: 5 mar. 2022.

DIMIDIJAN, S. et al. Web-based Mindfulness-based Cognitive Therapy for reducing residual depressive symptoms: An open trial and quasi-experimental comparison to propensity score matched controls. Behaviour Research and Therapy, [s. l.], 2014. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25461782/. Acesso em: 4 mar. 2022.

DUMAN, R. S.; SANACORA, G.; KRYSTAL, J. H. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron, [s. l.], 3 abr. 2019. Disponível em: https://www.cell.com/neuron/fulltext/S0896-6273(19)30220-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS089662731930220X%3Fshowall%3Dtrue. Acesso em: 12 mar. 2022.

FOROUGHI, A. et al. The effectiveness of mindfulness-based cognitive therapy for reducing rumination and improving mindfulness and self-compassion in patients with treatment-resistant depression. Trends Psychiatry Psychother., [s. l.], 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32696895/. Acesso em: 18 mar. 2022.

GRECUCCI, A. et al. Mindful Emotion Regulation: Exploring the Neurocognitive Mechanisms behind Mindfulness. BioMed Research International, [s. l.], 2015. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26137490/. Acesso em: 7 mar. 2022.

HOFMANN, S. G.; GÓMEZ, A. F. Mindfulness-Based Interventions for Anxiety and Depression. Psychiatric Clinics of North America, [s. l.], 2017. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29080597/. Acesso em: 18 mar. 2022.

JAISWAL, S. et al. Indices of association between anxiety and mindfulness: a guide for future mindfulness studies. Personality Neuroscience, [s. l.], 2019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32435744/. Acesso em: 10 mar. 2022.

KUYKEN, W. et al. The effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse/recurrence: results of a randomised controlled trial (the PREVENT study). Health Technology Assessment, [s. l.], 2015. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26379122/. Acesso em: 17 mar. 2022.

LI, H. et al. Mindfulness-Based Cognitive Therapy Regulates Brain Connectivity in Patients With Late-Life Depression. Frontiers in Psychiatry, [s. l.], 2022. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35237197/. Acesso em: 11 mar. 2022.

LI, J. et al. Mindfulness-based therapy versus cognitive behavioral therapy for people with anxiety symptoms: a systematic review and meta-analysis of random controlled trials. Annals of Palliative Medicine, [s. l.], 2021. Disponível em: https://apm.amegroups.com/article/view/73159/html. Acesso em: 3 mar. 2022.

LI, Y. et al. Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla. Magma, [s. l.], 2016. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26861048/. Acesso em: 15 mar. 2022.

LINDSAY, E. K.; CRESWELL, J. D. Mechanisms of Mindfulness Training: Monitor and Acceptance Theory (MAT). Clinical Psychology Review, [s. l.], 2017. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195874/. Acesso em: 9 mar. 2022.

MOSINI, A. C. et al. Neurophysiological, cognitive-behavioral and neurochemical effects in practitioners of transcendental meditation - A literature review. Revista da Associação Médica Brasileira, [s. l.], 2019. Disponível em: https://www.scielo.br/j/ramb/a/BWtGypq4PNSJT4x9kT56zjs/?lang=en. Acesso em: 23 fev. 2022.

NINOMIYA, A. et al. Effectiveness of mindfulness-based cognitive therapy in patients with anxiety disorders in secondary-care settings: A randomized controlled trial. Psychiatry and Clinical Neurosciences, [s. l.], 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31774604/. Acesso em: 10 mar. 2022.

PAHLEVAN, T.; UNG, C.; SEGAL, Z. Cost-Utility Analysis of Mindfulness-Based Cognitive Therapy Versus Antidepressant Pharmacotherapy for Prevention of Depressive Relapse in a Canadian Context. The Canadian Journal of Psychiatry, [s. l.], 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32031000/. Acesso em: 2 mar. 2022.

PINHO, P. H. et al. Mindfulness no contexto dos transtornos mentais: uma revisão integrativa. Rev. Eletrônica Saúde Mental Álcool Drog., [s. l.], 2020. Disponível em: http://pepsic.bvsalud.org/pdf/smad/v16n3/v16n3a12.pdf. Acesso em: 10 mar. 2022.

REANGSING, C.; LAUDERMAN, C.; SCHNEIDER, J. K. Effects of Mindfulness Meditation Intervention on Depressive Symptoms in Emerging Adults: A Systematic Review and Meta-Analysis. The Journal of Integrative and Complementary Medicine, [s. l.], 2022. Disponível em: https://www.liebertpub.com/doi/epdf/10.1089/jicm.2021.0036. Acesso em: 6 mar. 2022.

RENNA, M. E. et al. A Pilot Study of Emotion Regulation Therapy for Generalized Anxiety and Depression: Findings From a Diverse Sample of Young Adults. Behavior Therapy, [s. l.], 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29704969/. Acesso em: 3 mar. 2022.

RITVO, P. et al. An Online Mindfulness-Based Cognitive Behavioral Therapy Intervention for Youth Diagnosed With Major Depressive Disorders: Protocol for a Randomized Controlled Trial. JMIR Research Protocols, [s. l.], 2019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31359869/. Acesso em: 9 mar. 2022.

RODRIGUES, M. F.; NARDI, A. E.; LEVITAN, M. Mindfulness in mood and anxiety disorders: a review of the literature. Trends Psychiatry Psychother., [s. l.], 2017. Disponível em: https://www.scielo.br/j/trends/a/VvY3qDh5VDJmHVkGCTZbRjr/?lang=en. Acesso em: 15 mar. 2022.

SCHOENBERG, P. L. A.; SPECKENS, A. E. M. Multi-dimensional modulations of α and γ cortical dynamics following mindfulness-based cognitive therapy in Major Depressive Disorder. Cognitive Neurodynamics, [s. l.], 2015. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26052359/. Acesso em: 14 fev. 2022.

SHALLCROSS, A. J. et al. Relapse prevention in major depressive disorder: Mindfulness-based cognitive therapy versus an active control condition. Journal of Consulting and Clinical Psychology, [s. l.], 2015. Disponível em: https://pubmed.ncbi.nlm.nih.gov/26371618/. Acesso em: 12 mar. 2022.

SHAPERO, B. G. et al. Mindfulness-Based Interventions in Psychiatry. Focus, [s. l.], 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29599651/. Acesso em: 9 mar. 2022.

SILVA, A. C. et al. Plantas com ação no sistema nervoso central que constam na relação nacional de plantas medicinais de interesse ao SUS (RENISUS). Arquivos de Ciências da Saúde da UNIPAR, Umuarama, v. 26, n. 3, p. 1149-1162, set./dez. 2022. Disponível em: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1414432#:~:text=Destas%2C%20somente%20tr%C3%AAs%20esp%C3%A9cies%20apresentam,tamb%C3%A9m%20fazem%20parte%20da%20RENISUS.

STRÖHLE, A.; GENSICHEN, J.; DOMSCHKE, K. The Diagnosis and Treatment of Anxiety Disorders. Deutsches Ärzteblatt International, [s. l.], 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30282583/. Acesso em: 5 mar. 2022.

TANG, Y.; LEVE, L. D. A translational neuroscience perspective on mindfulness meditation as a prevention strategy. Translational Behavioral Medicine, [s. l.], 2016. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27012254/. Acesso em: 11 mar. 2022.

VELDEN, A. M. et al. A systematic review of mechanisms of change in mindfulness-based cognitive therapy in the treatment of recurrent major depressive disorder. Clinical Psychology Review, [s. l.], 2015. Disponível em: https://www.sciencedirect.com/science/article/pii/S0272735815000203. Acesso em: 7 mar. 2022.

WALSH, E.; EISENLOHR-MOUL, T.; BAER, R. Brief mindfulness training reduces salivary IL-6 and TNF-α in young women with depressive symptomatology. Journal of Consulting and Clinical Psychology, [s. l.], 2016. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27281371/. Acesso em: 3 mar. 2022.

ZEIDAN, F. et al. Neural correlates of mindfulness meditation-related anxiety relief. Social Cognitive and Affective Neuroscience, [s. l.], 2014. Disponível em: https://pubmed.ncbi.nlm.nih.gov/23615765/. Acesso em: 13 mar. 2022.

Downloads

Publicado

22-09-2023

Como Citar

MACHADO, Bárbara Martins; KOURY, Lara; DA SILVA, Thiago Donizeth; MARQUES, Petrus Pires; SAEZ, Daniel Martinez; SOARES, Evelise Aline; GUERRA, Flávia Da Ré. IMPLICAÇÕES NEUROLÓGICAS DA MEDITAÇÃO DO TIPO TERAPIA COGNITIVA BASEADA EM MINDFULNESS EM PACIENTES COM TRANSTORNO DE ANSIEDADE OU TRANSTORNO DEPRESSIVO: UMA REVISÃO INTEGRATIVA. Arquivos de Ciências da Saúde da UNIPAR, [S. l.], v. 27, n. 9, p. 5142–5162, 2023. DOI: 10.25110/arqsaude.v27i9.2023-016. Disponível em: https://unipar.openjournalsolutions.com.br/index.php/saude/article/view/10599. Acesso em: 21 dez. 2024.

Edição

Seção

Artigos