METABÓLITOS BIOATIVOS E ATIVIDADES BIOLÓGICAS, TÓXICAS E FARMACOLÓGICAS DE PLANTAS ORNAMENTAIS: UMA REVISÃO DAS ESPÉCIES HYDRANGEA MACROPHYLLA, EUPHORBIA MILII, DIEFFENBACHIA SEGUINE E DRACAENA TRIFASCIATA

Autores

  • Maria Madalena Gabriel
  • Fernando Cesar Martins Betim
  • Camila Freitas de Oliveira
  • Aline Bianchini
  • Paula Francislaine Moura
  • Luciane Dalarmi
  • Idonilton da Conceição Fernandes
  • Josiane de Fátima Gaspari Dias
  • Obdulio Gomes Miguel
  • Marilis Dallarmi Miguel

DOI:

https://doi.org/10.25110/arqsaude.v27i6.2023-032

Palavras-chave:

Plantas Ornamentais, Atividade Tóxica, Atividade Biológica, Atividade Farmacológica

Resumo

As plantas ornamentais foram selecionadas pelo homem a partir de caracteres atraentes e começaram a ser cultivadas por sua beleza. São utilizadas frequentemente em arquitetura e paisagismo de espaços externos, porém, pode possuir princípios ativos que as tornam tóxicas e que podem causar danos a saúde como irritações na pele e mucosas. No Brasil há descritas diversas plantas de uso ornamental e que são consideradas tóxicas, dentre elas podemos destacar popularmente hortênsia, comigo-ninguém-pode, espada-de-são-jorge e a coroa-de-cristo e na literatura o envenenamento humano por essas plantas tóxicas quase não é documentado o que despertou interesse nessa revisão. Logo, esse estudo possui objetivo de revisar as bases de dados em busca de informações de atividades biológicas, tóxicas, farmacológicas e de metabólitos bioativos das espécies Hydrangea macrophylla, Euphorbia milii, Dieffenbachia seguine e Dracaena trifasciata. Para o compilado de dados deste artigo de revisão, foram utilizados 51 artigos que reuniram as condições de elegibilidade buscadas. Os artigos foram lidos na integra e os dados agregados em tabela ou texto. Esta revisão observou que a maioria dos ensaios aplicados nessas espécies foram de caráter toxicológico e objetivavam a busca de veículos para controle de doenças ocasionadas por vetores. Os ensaios demonstraram potencial tóxico preliminar, justificando os efeitos relacionados à intoxicação ou aos danos á saúde como irritações na pele e mucosas.

Referências

ABDUL-HAFEEZ, E. Y. et al. In vitro cytotoxic activity of certain succulent plants against human colon, breast and liver cancer cell lines. South African Journal of Botany, v. 131, p. 295-301, 2022. https://doi.org/10.1016/j.sajb.2020.02.023

AFONSO-NETO, I. S.; BESSA, E. A.; SOARES, G. L. G. Avaliação da atividade moluscicida do látex de três espécies de Euphorbia (Euphorbiaceae) sobre Leptinaria unilamellata d'Orbigny, 1835 (Gastropoda-Subulinidae). Revista Brasileira de Plantas Medicinais, v. 12, p. 90-95, 2010. doi.org/10.1590/S1516-05722010000100013

AKANDA, M. R. et al. Hepatoprotective role of Hydrangea macrophylla against sodium arsenite-induced mitochondrial-dependent oxidative stress via the inhibition of MAPK/Caspase-3 pathways. International Journal of Molecular Sciences, v. 18, n. 7, p. 1482, 2017 https://doi. org./10.3390/ijms18071482.

ALBERTO-SILVA, A. C., et al. Behavioral response of Biomphalaria glabrataexposed to a sublethal concentration of Euphorbia miliivar. hislopii latex. Anais da Academia Brasileira de Ciências, v. 92, 2020. https://doi.org/10.1590/0001-3765202020190298.

ANBU, J. S. J. et al. Analgesic and antipyretic effects of Sansevieria trifasciata leaves. African Journal of Traditional, Complementary, and Alternative Medicines, v. 6, n. 4, p. 529, 2009.

ANDHARE, R. N.et al.Evaluation of antiallergic and anti-anaphylactic activity of ethanolic extract of Sanseveiria trifasciata leaves (EEST) in rodents. Journal of ethnopharmacology, v. 142, n. 3, p. 627-633, 2012 https://doi.org/10.1016/j.jep.2012.05.007.

FERNANDO, F. C. B., et al. Estudo fitoquímico de Euphorbia tirucalli L.(avelós), atividade antimicrobiana e ensaios toxicológicos preliminares in vitro. Revista Cubana de Plantas Medicinales, v. 22, n. 3, 2017.

CAMPOS, S. C. et al. Toxicidade de espécies vegetais. Revista Brasileira de plantas medicinais, v. 18, p. 373-382, 2016.https://dx.doi.org/10.1590/1983-084X/15_057

CHOHAN, T. Aet al. Phytochemical profiling, antioxidant and antiproliferation potential of Euphorbia milii var.: Experimental analysis and in-silico validation. Saudi Journal of Biological Sciences, v. 27, n. 11, p. 3025-3034, 2020. https://doi.org/10.1016/j.sjbs.2020.08.003.

SILVA, A. C. da.; DIAS, A. B.; GAZIM, Z. C.; RAHAL, I. L.; LAGINESTRA, B. de. F. A.; SILVA, G. C. C.; JUNIOR, R. P. Plantas com ação no sistema nervoso central que constam na relação nacional de plantas medicinais de interesse ao SUS(RENISUS). Arquivos de Ciências da Saúde da UNIPAR. Umuarama. v. 26, n. 3, p. 1149-1162, set./dez. 2022.

DE-CARVALHO, R. R. et al. Effects of Euphorbia milii latex on Schistosoma mansoni eggs, miracidia and cercariae. Memórias do Instituto Oswaldo Cruz, v. 93, p. 235-237, 1998.https://doi.org/10.1590/S0074-02761998000700042.

DELGADO, I.F; PAUMGARTTEN, F. J. R. Effects of Euphorbia milii latex on mitogen-induced lymphocyte proliferation. Revista Brasileira de Plantas Medicinais, v. 16, p. 107-111, 2014. https://doi.org/10.1590/S1516-05722014000100015.

FEBRIANI, Y., et al. Antibacterial activity of lidah mertua (Sansevieria trifasciata Prain.) leaves extract on Escherichia coli and Staphylococcus aureus. Open Access Macedonian Journal of Medical Sciences, v. 7, n. 22, p. 3882, 2019. https://doi: 10.3889/oamjms.2019.525.

FENG, W. S. et al. A new flavonol glycoside from Hydrangea macrophylla (Thunb.) Seringe. Chinese Chemical Letters, v. 21, n. 6, p. 690-692, 2010.https://doi.org/10.1016/j.cclet.2010.02.002.

GONZÁLEZ, A. G. et al. New sources of steroid sapogenins—XIV: 25S-ruscogenin and sansevierigenin, two new spirostan sapogenins from Sansevieria trifasciata. Tetrahedron, v. 28, n. 5, p. 1289-1297, 1972. https://doi.org/10.1016/S0040-4020(01)93553-7.

GORHAM, J. Lunularic acid and related compounds in liverworts, algae and Hydrangea. Phytochemistry, v. 16, n. 2, p. 249-253, 1977. https://doi.org/10.1016/S0031-9422(00)86795-3.

GUPTA, A; GUPTA, R. A survey of plants for presence of cholinesterase activity. Phytochemistry, v. 46, n. 5, p. 827-831, 1997. https://doi.org/10.1016/S0031-9422(97)00393-2.

HASHIMOTO, T; TORI, M; ASAKAWA, Y. Three dihydroisocoumarin glucosides from Hydrangea macrophylla subsp. serrata. Phytochemistry, v. 26, n. 12, p. 3323-3330, 1987.https://doi.org/10.1016/S0031-9422(00)82497-8.

IGHODARO, O. M., et al. Toxicity status and antiulcerative potential of Sansevier-ia trifasciata leaf extract in Wistar rats. Journal of Intercultural Ethnopharmacology, v. 6, n. 2, p. 234, 2017. doi: 10.5455/jice.20170421103553.

INOUYE, H. et al. A novel type secoiridoid glucoside, hydrangenoside A from Hydrangea macrophylla. Tetrahedron Letters, v. 21, n. 11, p. 1059-1062, 1980. https://doi.org/10.1016/S0040-4039(00)78838-1.

ISHIH, A., et al. A potent antimalarial activity of Hydrangea macrophylla var. Otaksa leaf extract against Plasmodium yoelii 17XL in mice. Parasitology International, v. 50, n. 1, p. 33-39, 2001. doi: 10.1016/s1383-5769(00)00069-6.

KAMEI, K. et al. Anti-malarial activity of leaf-extract of Hydrangea macrophylla, a common Japanese plant. Acta Medica Okayama, v. 54, n. 5, p. 227-232, 2000. https://doi. org./10.18926/AMO/32291.

LINE-EDWIGE, M., et al. Antiproliferative effect of alcoholic extracts of some Gabonese medicinal plants on human colonic cancer cells. African Journal of Traditional, Complementary and Alternative Medicines, v. 6, n. 2, 2009. doi: 10.4314/ajtcam. v6i2.57081.

LIU, J et al. Hydrangeamines A and B, novel polyketide-type pseudoalkaloid-coupled secoiridoid glycosides from the flowers of Hydrangea macrophylla var. thunbergii. Tetrahedron Letters, v. 54, n. 1, p. 32-34, 2013. https://doi.org/10.1016/j.tetlet.2012.10.052.

LIU, J. et al. Medicinal Flowers. XXXX. 1) Structures of dihydroisocoumarin glycosides and inhibitory effects on aldose reducatase from the flowers of Hydrangea macrophylla var. thunbergii. Chemical and Pharmaceutical bulletin, v. 61, n. 6, p. 655-661, 2013. doi: 10.1248/cpb.c13-00160.

LUBIAN, C., et al. Anthelmintic activity of plant aqueous extracts against Panagrellus redivivus in vitro. Arquivos do Instituto Biológico, v. 86, 2019. https://doi.org/10.1590/1808-1657000672018.

KIKUCHI, M., et al. Three New Glycosides from the Leaves of Hydrangea macrophylla subsp. serrata (T HUNB.) M AKINO. Chemical and Pharmaceutical Bulletin, v. 56, n. 4, p. 610-611, 2008. https://doi.org/10.1248/cpb.56.610

MANS, D. R. A. et al. In vitro evaluation of traditionally used Surinamese medicinal plants for their potential anti-leishmanial efficacy. Journal of ethnopharmacology, v. 180, p. 70-77, 2016. https://doi.org/10.1016/j.jep.2016.01.012.

MATSUDA, H., et al. Chemical constituents from the leaves of Hydrangea macrophylla var. thunbergii (III): Absolute stereostructures of hydramacrosides A and B, secoiridoid glucoside complexes with inhibitory activity on histamine release. Chemical and pharmaceutical bulletin, v. 47, n. 12, p. 1753-1758, 1999. doi: 10.1248/cpb.47.1753.

MIMAKI, Y., et al. Steroidal saponins from Sansevieria trifasciata. Phytochemistry, v. 43, n. 6, p. 1325-1331, 1996. https://doi.org/10.1016/S0031-9422(96)00397-4.

MIMAKI, Y. et al. Pregnane glycosides from Sansevieria trifasciata. Phytochemistry, v. 44, n. 1, p. 107-111, 1997.https://doi.org/10.1016/S0031-9422(96)00477-3.

MONSENY, A. M., et al. Poisonous plants: an ongoing problem. Anales de Pediatría (English Edition), v. 82, n. 5, p. 347-353, 2015. https://doi.org/10.1016/j.anpede.2014.08.006

NAKAMURA, S., et al. The absolute stereostructures of cyanogenic glycosides, hydracyanosides A, B, and C, from the leaves and stems of Hydrangea macrophylla. Tetrahedron Letters, v. 50, n. 32, p. 4639-4642, 2009. https://doi.org/10.1016/j.tetlet.2009.05.111.

OLIVEIRA‐FILHO, E. C.; DE‐CARVALHO, R. R.; PAUMGARTTEN, F. J. R. The influence of environmental factors on the molluscicidal activity of Euphorbia milii latex. Journal of Environmental Science & Health Part B, v. 34, n. 2, p. 289-303, 1999. doi: 10.1080/03601239909373198.

OLIVEIRA-FILHO, E. C. et al. Comparative toxicity of Euphorbia milii latex and synthetic molluscicides to Biomphalaria glabrata embryos. Chemosphere, v. 81, n. 2, p. 218-227, 2010.https://doi.org/10.1016/j.chemosphere.2010.06.038.

OLIVEIRA-FILHO, E. C.; PAUMGARTTEN, F. JR. Toxicity of Euphorbia milii latex and niclosamide to snails and nontarget aquatic species. Ecotoxicology and environmental safety, v. 46, n. 3, p. 342-350, 2000. https://doi.org/10.1006/eesa.2000.1924.

OLIVEIRA-FILHO, E. C.; PAUMGARTTEN, F. J. R. Photodegradation of the Molluscicidal Latex of" Crown-of-Thorns"(Euphorbia milii var hislopii). Memórias do Instituto Oswaldo Cruz, v. 92, p. 657-659, 1997.https://doi.org/10.1590/S0074-02761997000500018.

PILE, E., et al. Fasciolose bovina: controle com látex da" coroa-de-Cristo"(Euphorbia splendens var. hislopii). Brazilian Journal of Veterinary Research and Animal Science, v. 38, p. 288-289, 2001. https://doi.org/10.1590/S1413-95962001000600008.

SAIFUDIN, A., et al. Bioprospecting for anti-Streptococcus mutans: The activity of 10% Sesbania grandiflora flower extract comparable to erythromycin. Asian Pacific Journal of Tropical Biomedicine, v. 6, n. 9, p. 751-754, 2016. https://doi.org/10.1016/j.apjtb.2016.07.004.

SALEEM, H. et al. In vitro biological propensities and chemical profiling of Euphorbia milii Des Moul (Euphorbiaceae): A novel source for bioactive agents. Industrial Crops and Products, v. 130, p. 9-15, 2019. https://doi.org/10.1016/j.indcrop.2018.12.062.

SERMSART, B. et al. The molluscicidal activities of some Euphorbia milii hybrids against the snail Indoplanorbis exustus. Southeast Asian journal of tropical medicine and public health, v. 36, p. 192, 2005.

SIKDER, Md Al A.et al. In vitro antimicrobial screening of four reputed Bangladeshi medicinal plants. Pharmacognosy Journal, v. 3, n. 24, p. 72-76, 2011. https://doi.org/10.5530/pj.2011.24.14.

SILVA, L. C. Plantas ornamentais tóxicas presentes no shopping Riverside Walk em Teresina–PI. Revista da Sociedade Brasileira de Arborização Urbana, v. 4, n. 3, p. 69-85, 2009. http://dx.doi.org/10.5380/revsbau.v4i3.66412

SILVA, E. I; SANTOS, J; CONCEIÇÃO, G. Diversidade de plantas ornamentais no centro de estudos superiores de Caxias, da Universidade Estadual do Maranhão. Enciclopédia Biosfera, v. 10, n. 18, 2014.

SOUZA, C. A. M. et al. Study of the embryofeto-toxicity of Crown-of-Thorns (Eu-phorbia milii) latex, a natural molluscicide. Brazilian journal of medical and biological research, v. 30, p. 1325-1332, 1997. https://doi.org/10.1590/S0100-879X1997001100011.

SUZUKI H., MATSUMOTO T., NOGUCHI M. (1976). Identification of p-aminophenyl-α-0D-glucose from Hydrangea macrophylla. Phytochemistry 15 (4), 555. https://doi.org/10.1016/S0031-9422(00)88972-4.

TCHEGNITEGNI, B. T. et al. A dihydrochalcone derivative and further steroidal saponins from Sansevieria trifasciata Prain. Zeitschrift für Naturforschung C, v. 72, n. 11-12, p. 477-482, 2017. doi: 10.1515/znc-2017-0027.

TCHEGNITEGNI, Billy T. et al. Sappanin-type homoisoflavonoids from Sansevieria trifasciata Prain. Phytochemistry Letters, v. 12, p. 262-266, 2015. https://doi.org/10.1016/j.phytol.2015.04.017.

TEPONNO, R. B. et al. Trifasciatosides A–J, steroidal saponins from Sansevieria trifasciata. Chemical and Pharmaceutical Bulletin, v. 64, n. 9, p. 1347-1355, 2016.doi: 10.1248/cpb.c16-00337.

VÁSQUEZ-OCMÍN, P., et al. Antiprotozoal activity of medicinal plants used by Iquitos-Nauta road communities in Loreto (Peru). Journal of Ethnopharmacology, v. 210, p. 372-385, 2018.https://doi.org/10.1016/j.jep.2017.08.039.

WANG, Zhi-Bin et al. Chemical constituents from Hydrangea macrophylla. Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica, v. 38, n. 5, p. 709-713, 2013.

YADAV, S. C.; JAGANNADHAM, M. V. Physiological changes and molluscicidal effects of crude latex and Milin on Biomphalaria glabrata. Chemosphere, v. 71, n. 7, p. 1295-1300, 2008.doi: 10.1016/j.chemosphere.2007.11.068.

YAMAHARA, J. et al. Development of bioactive functions in hydrangeae dulcis folium. II. Antiulcer, antiallergy, and cholagoic effects of the extract from hydrangeae dulcis folium. Yakugaku zasshi: Journal of the Pharmaceutical Society of Japan, v. 114, n. 6, p. 401-413, 1994. doi: 10.1248/yakushi1947.114.6_401.

YANG, Chun-Juan et al. Two new cyanogenic glucosides from the leaves of Hydrangea macrophylla. Molecules, v. 17, n. 5, p. 5396-5403, 2012.https://doi.org/10.3390/molecules17055396.

YOSHIKAWA, Masayuki et al. Absolute stereostructures of hydramacrosides A and B, new bioactive secoiridoid glucoside complexes from the leaves of Hydrangea macrophylla Seringe var. thunbergii Makino. Chemical and pharmaceutical bulletin, v. 42, n. 8, p. 1691-1693, 1994. doi: 10.1248/cpb.42.1691.

ZANI, Carlos Leomar et al. Molluscicidal milliamines from Euphorbia milii var. hislopii. Phytochemistry, v. 34, n. 1, p. 89-95, 1993.https://doi.org/10.1016/S0031-9422(00)90788-X.

ZHANG, H., et al. New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Bioorganic & medicinal chemistry letters, v. 17, n. 17, p. 4972-4976, 2007.https://doi.org/10.1016/j.bmcl.2007.06.027.

Downloads

Publicado

14-06-2023

Como Citar

GABRIEL, Maria Madalena et al. METABÓLITOS BIOATIVOS E ATIVIDADES BIOLÓGICAS, TÓXICAS E FARMACOLÓGICAS DE PLANTAS ORNAMENTAIS: UMA REVISÃO DAS ESPÉCIES HYDRANGEA MACROPHYLLA, EUPHORBIA MILII, DIEFFENBACHIA SEGUINE E DRACAENA TRIFASCIATA. Arquivos de Ciências da Saúde da UNIPAR, [S. l.], v. 27, n. 6, p. 2623–2640, 2023. DOI: 10.25110/arqsaude.v27i6.2023-032. Disponível em: https://unipar.openjournalsolutions.com.br/index.php/saude/article/view/10233. Acesso em: 24 nov. 2024.

Edição

Seção

Artigos